Research articles
Zinc supplementation in chronic kidney disease of unknown aetiology in Sri Lanka: a pilot study. (ZisCKDu-P)
Authors:
P. K. Abeysundara ,
Ashraff Memorial Hospital, Kalmunai, LK
N. Nishad,
University of Colombo, LK
About N.
Post Graduate Institute of Medicine
S. T. De Silva,
University of Kelaniya, LK
About S. T.
Faculty of Medicine
R. T. Dassanayake,
Provincial General Hospital, Kurunegala, LK
D. P. Galabada,
District General Hospital, Polonnaruwa, LK
U. G. W. Jayawardane,
District General Hospital, Polonnaruwa, LK
N. P. Premawardana,
District General Hospital, Monaragala, LK
G. M. S. S. Kumara,
University of Colombo, LK
About G. M. S. S.
Post Graduate Institute of Medicine
P. M. Dilani,
University of Kelaniya, LK
About P. M.
Faculty of Medicine
H. M. T. D. Herath,
University of Kelaniya, LK
About H. M. T. D.
Faculty of Medicine
P. S. Wijesinghe
University of Kelaniya, LK
About P. S.
Faculty of Medicine
Abstract
Introduction: It was hypothesized that the antioxidant properties of zinc retard the progression of chronic kidney disease of unknown etiology in the North Central Province of Sri Lanka.
Methods: The pilot study was a randomized, placebo-controlled, single blinded, parallel group, single-center clinical trial with two arms (Z and P) and a 1:1 allocation ratio. Participants in group Z (n=20) received 60 mg of elemental zinc daily, in the form of zinc sulfate, and group P (n=21) received a starch tablet per day. Clinical, hematological parameters and kidney function were measured at the baseline and following three months of the intervention.
Results: A total of 86 CKDu patients were screened; only 35 males and 6 females were selected. Mean age and estimated glomerular filtration rate of the study population were 51.2±6.2 years and 38.9±8.8 mL/min/1.73 m2 respectively. At the end of three months there was non-significant increase in urine protein creatinine ratio (Z arm: 65±54 vs. 82± 86 mg/mmol; P=0.46, P arm: 72.4±113 vs. 120± 209 mg/mmol; P=0.36) and non-significant decline in estimated glomerular filtration rate (Z arm: 40.9±10.4 vs. 39.7±9.2 mL/min/1.73 m2; P=0.31, P arm: 37.1±6.8 vs. 36.4±10 mL/min/1.73m2; P=0.31) in both groups. Body mass index was significantly reduced (23±4 vs. 22.7± 3.9 kg/m2; P=0.01) and diastolic blood pressure was significantly increased (78±6 vs. 86±10 mmHg; P=0.001) in the placebo arm. Haemoglobin levelshowed a decline in the study group; 0.33±1 g/dl, while there was an increase in the placebo group, 0.34±0.7 g/dl, (P=0.02). There were no major side effects.
Conclusions: The change of urine protein: creatinine ratio and estimated glomerular filtration rate did not show a significant difference between the two groups. A future trial should test effectiveness of same dose of zinc for a similar duration of time in a larger sample. Extended follow-up of the study subjects for one year after the intervention would be useful to assess the long-term effects of zinc on kidney function and side effects.
How to Cite:
Abeysundara, P.K., Nishad, N., De Silva, S.T., Dassanayake, R.T., Galabada, D.P., Jayawardane, U.G.W., Premawardana, N.P., Kumara, G.M.S.S., Dilani, P.M., Herath, H.M.T.D. and Wijesinghe, P.S., 2020. Zinc supplementation in chronic kidney disease of unknown aetiology in Sri Lanka: a pilot study. (ZisCKDu-P). Journal of the Ceylon College of Physicians, 51(2), pp.82–90. DOI: http://doi.org/10.4038/jccp.v51i2.7901
Published on
14 Dec 2020.
Peer Reviewed
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