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Dextran induced acute kidney injury in a patient with dengue haemorrhagic fever

Authors:

M. P. Priyacharana ,

Colombo South Teaching Hospital, LK
About M. P.
University Medical Unit
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M. H. S. Sumanadasa,

Colombo South Teaching Hospital, LK
About M. H. S.
University Medical Unit
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P. D. K. Thiranagama,

Colombo South Teaching Hospital, LK
About P. D. K.
Histopathology Unit
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A. Marasinghe,

Colombo South Teaching Hospital, LK
About A.
Nephrology Unit
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N. L. A. Shyamali

Colombo South Teaching Hospital
About N. L. A.
University Medical Unit

Department of Medicine, Faculty of Medical Sciences, University of Sri Jayewardenepura
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Abstract

Dextran 40 is a low molecular weight dextran preparation which is used as an adjunctive treatment in hypovolemic shock. At present dextran 40 is mainly used in the clinical practice for management of severe cases of dengue haemorrhagic fever or dengue shock syndrome. Acute kidney injury is a rare adverse reaction of dextran administration. We report a case of dextran induced acute kidney injury complicated with hypertensive encephalopathy during the convalescent phase of the illness. Renal biopsy revealed fine isometric vacuolations of tubular epithelial cells suggestive of osmotic nephrosis.

How to Cite: Priyacharana, M.P., Sumanadasa, M.H.S., Thiranagama, P.D.K., Marasinghe, A. and Shyamali, N.L.A., 2019. Dextran induced acute kidney injury in a patient with dengue haemorrhagic fever. Journal of the Ceylon College of Physicians, 50(1), pp.41–43. DOI: http://doi.org/10.4038/jccp.v50i1.7866
Published on 04 Dec 2019.
Peer Reviewed

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