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Reading: Accuracy of selected indicators in leaking for the management of dengue haemorrhagic fever

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Accuracy of selected indicators in leaking for the management of dengue haemorrhagic fever

Authors:

K. N. P. Ranasinghe ,

Base Hospital, Horana, LK
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K. A. A. Dilhari,

University of Sri Jayewardenepura, LK
About K. A. A.
Department of Microbiology, Faculty of Medical Sciences
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G. Dissanayake,

Base Hospital, Horana, LK
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K. Vigneswaran,

Base Hospital, Horana, LK
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A. M. H. Chinthaka,

Base Hospital, Horana, LK
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M. I. Mujahieth

Base Hospital, Horana, LK
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Abstract

Aims: Conventional clinical and laboratory parameters for the management of dengue haemorrhagic fever (DHF) were validated using ultrasound scan (USS) as the gold standard.

 

Methods: Clinically suspected 184 patients with platelet count <100,000 were enrolled in the study.

 

Results: USS evidence of leaking was observed in 48% of the sample. When Hct rises >10% and >20% were used as a predictor of leaking, sensitivity and specificity of 30%, 82% (PPV 60%, NPV 56%) and 11%, 94% (PPV 63% and NPV 54%) were observed. Liver tenderness and gall bladder wall oedema (wall thickness>6mm) had sensitivity of 28%, 91% and specificity of 83% and 94% as predictors of leaking. Haematocrit rise > 10% during any stage of critical phase associated with 94% sensitivity and 37% specificity (PPV 46%, NPV 92%) in prediction of complications.

 

Conclusions: Rising HCT, liver tenderness and clinical detection were found to be weak predictors of onset of leaking. HCT rise was a strong predictor of complications during the leaking phase.

How to Cite: Ranasinghe, K.N.P., Dilhari, K.A.A., Dissanayake, G., Vigneswaran, K., Chinthaka, A.M.H. and Mujahieth, M.I., 2018. Accuracy of selected indicators in leaking for the management of dengue haemorrhagic fever. Journal of the Ceylon College of Physicians, 49(1), pp.25–29. DOI: http://doi.org/10.4038/jccp.v49i1.7843
Published on 29 Jun 2018.
Peer Reviewed

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