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Case Reports

Membranoproliferative glomerulonephritis associated with hyperthyroid phase of autoimmune thyroiditis

Authors:

G. G. A Gayani ,

Teaching Hospital Karapitiya, Galle, LK
About G. G. A
Registrar in Medicine, University Medical Unit
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H. M. A. Ediriweera,

Teaching Hospital Karapitiya, Galle, LK
About H. M. A.
Registrar in Medicine, University Medical Unit
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S. Heiyanthuduwa,

Teaching Hospital Karapitiya, Galle, LK
About S.
Consultant Nephrologist
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A. Perera,

Teaching Hospital Karapitiya, Galle, LK
About A.
Consultant Histopathologist
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A. Dissanayake,

University of Ruhuna, Galle, LK
About A.
Consultant Physician, Senior Lecturer in Medicine,
Department of Medicine, Faculty of Medicine
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T. P. Weerarathne

University of Ruhuna, Galle, LK
About T. P.
Professor in Medicine, Department of Medicine,
Faculty of Medicine
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Abstract

Several cases of glomerulonephritis have been associated with autoimmune thyroid diseases. Most frequent renal lesion described was membranous glomerulonephritis presenting with nephrotic syndrome. This is a case history of a 58-year-old male presenting with nephrotic syndrome secondary to membranoproliferative glomerulonephritis and associated autoimmune thyroiditis. Hisserum complement levels were decreased with high titres of circulating antithyroid peroxidase antibodies and thyrotropin receptor antibodies. Renal biopsy showed membranoproliferative glomerulonephritis with the finding of increased tuft cellularity, lobular accentuation,neutrophilinfiltratedglomeruli and thickened basement membrane. Antithyroid drugs along with steroids led to significant reduction in proteinuria and resolution of oedema.

How to Cite: Gayani, G.G.A. et al., (2016). Membranoproliferative glomerulonephritis associated with hyperthyroid phase of autoimmune thyroiditis. Journal of the Ceylon College of Physicians. 47(1), pp.44–45. DOI: http://doi.org/10.4038/jccp.v47i1.7769
Published on 27 Sep 2016.
Peer Reviewed

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