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Streptokinase in STEMI: ninety minute ECG for ST resolution; experience in an acute medical unit

Authors:

Padmalal Gurugama ,

Professorial Medical Unit, Colombo South Teaching Hospital, Kalubowila, Sri Lanka., LK
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Anne Thushara Matthias,

Professorial Medical Unit, Colombo South Teaching Hospital, Kalubowila, Sri Lanka., LK
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Jeyanthi Rajkannah,

Professorial Medical Unit, Colombo South Teaching Hospital, Kalubowila, Sri Lanka., LK
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Thambaiah Kandeepan,

Professorial Medical Unit, Colombo South Teaching Hospital, Kalubowila, Sri Lanka., LK
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Jeganathan Indrakumar,

Department of Medicine, University of Sri Jayewardenepura, Gangodawila, Nugegoda, Sri Lanka., LK
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Saman B Gunatilake

Department of Medicine, University of Sri Jayewardenepura, Gangodawila, Nugegoda, Sri Lanka., LK
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Abstract

Abstarct

Streptokinase is the main thrombolytic used for the management of ST Elevated Myocardial Infarctions (STEMI) in Sri Lanka. We assessed the efficacy of streptokinase in restoring myocardial perfusion following acute STEMI. One hundred and eight patients were studied. Sixty eight (56%) patients responded to streptokinase. Forty five (41.7%) had anterior STEMI and 20 (44.4%) responded (p=<0.001). Forty four had inferior STEMI and 32 (72.7%) responded (p=0.007). Fifteen had antero-lateral STEMI and 13.3% responded. Time from the onset of pain to arrival at hospital was 137 in responders and 339 minutes in non responders (p=0.004). Eight (11.8%) responders and four (10%) non responders were on aspirin. Thirty two (47.1%) responders and 16 (40%) non responders were smokers. Twenty (29.4%) responders and 9 (22.5%) non responders were having diabetes mellitus. Considerably higher percentage responded to streptokinase. Inferior myocardial infarctions have significantly high reperfusion rates. Delayed hospital admission had a major impact in the non responders.

 

DOI:http://dx.doi.org/10.4038/jccp.v43i1-2.6814

 

Journal of the Ceylon College of Physicians,2012, 43, 32-36

DOI: http://doi.org/10.4038/jccp.v43i1-2.6814
How to Cite: Gurugama, P. et al., (2014). Streptokinase in STEMI: ninety minute ECG for ST resolution; experience in an acute medical unit. Journal of the Ceylon College of Physicians. 43(1-2), pp.32–36. DOI: http://doi.org/10.4038/jccp.v43i1-2.6814
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Published on 09 Apr 2014.
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